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biossusa/mTOR (Ser2481) Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/bs-3495R-A680/100ul

biossusa/mTOR (Ser2481) Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/bs-3495R-A680/100ul
  • biossusa/mTOR (Ser2481) Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/bs-3495R-A680/100ul
商品介绍
Overview
Catalog #bs-3495R-A680
Product NamemTOR (Ser2481) Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated
ApplicationsIF(IHC-P)
SpecificityThis phosphorylation site is homologous in the listed cross reactive species at the specified location.
ReactivityHuman, Mouse, Rat
Specifications
ConjugationALEXA FLUOR® 680
HostRabbit
SourceKLH conjugated synthetic phosphopeptide derived from human mTOR around the phosphorylation site of Ser2481
Immunogen Range2450-2500/2549
Modification SiteSer2481
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
StorageAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Target
Gene ID2475
Swiss ProtP42345
Subcellular locationCytoplasm, Nucleus, Mitochondrion, Lysosome, Cell membrane
SynonymsFRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
BackgroundSerine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
Application Dilution
IF(IHC-P)1:50-200
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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