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biossusa/P38 MAPK Polyclonal Antibody, FITC Conjugated/100ul/bs-0637R-FITC

  • 产品编号: bs-0637R-FITC
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类:
  • 公司分类: Primary Antibodies
biossusa/P38 MAPK Polyclonal Antibody, FITC Conjugated/100ul/bs-0637R-FITC
  • biossusa/P38 MAPK Polyclonal Antibody, FITC Conjugated/100ul/bs-0637R-FITC
商品介绍
Overview
Catalog #bs-0637R-FITC
Product NameP38 MAPK Polyclonal Antibody, FITC Conjugated
ApplicationsFCM, IF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman, Mouse, Rat
Predicted ReactivityDog, Rabbit
Specifications
ConjugationFITC
HostRabbit
SourceKLH conjugated synthetic peptide derived from human P38MAPK
Immunogen Range141-240/360
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID1432
Swiss ProtQ16539
Subcellular locationCytoplasm, Nucleus
SynonymsRK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; MAPK14
BackgroundThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Application Dilution
FCM1:20-100
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

Bioss Inc是领先的抗体开发人员和制造商,拥有最先进的技术。我们已经开发了11,000多种一抗和130,000多种衍生产品,包括与荧光染料偶联的抗体。除了可靠的上样控制和标签抗体外,我们的目录还包括1000多种识别具有磷酸化,乙酰化或甲基化修饰的蛋白质的特异性抗体。我们公司承诺以强大,优质的科学支持快速交货。Bioss Inc位于马萨诸塞州的大波士顿地区,该地区是世界上最大,发展最快的生物技术社区的中心。


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biossusa的羧肽酶,将血管紧张素I转变为功能未知的肽血管紧张素1-9,并将血管紧张素II转变为血管扩张剂的血管紧张素1-7。还能够高效水解apelin-13和dynorphin-13。可能是心脏功能的重要调节剂。在人类冠状病毒感染SARS和HCoV-NL63的情况下,可充当两种冠状病毒突突糖蛋白的功能受体。

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