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biossusa/IRF7 (Ser471 + Ser472) Antibody, Cy7 Conjugated/100ul/bs-3196R-Cy7

  • 产品编号: bs-3196R-Cy7
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类:
  • 公司分类: Primary Antibodies
biossusa/IRF7 (Ser471 + Ser472) Antibody, Cy7 Conjugated/100ul/bs-3196R-Cy7
  • biossusa/IRF7 (Ser471 + Ser472) Antibody, Cy7 Conjugated/100ul/bs-3196R-Cy7
商品介绍
Overview
Catalog #bs-3196R-Cy7
Product NameIRF7 (Ser471 + Ser472) Antibody, Cy7 Conjugated
ApplicationsFCM
ReactivityHuman, Mouse, Rat
Predicted ReactivityCow, Pig, Horse
Specifications
ConjugationCy7
HostRabbit
SourceKLH conjugated synthetic phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472
Modification SiteSer471 + Ser472
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID3665
Swiss ProtQ92985
Subcellular locationCytoplasm, Nucleus
SynonymsIRF7A; IRF7B; IRF7C; IRF7H; IRF-7H; Interferon regulatory factor 7; IRF-7; IRF7
BackgroundKey transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
Application Dilution
FCM1:20-100
品牌介绍

Bioss Inc是领先的抗体开发人员和制造商,拥有最先进的技术。我们已经开发了11,000多种一抗和130,000多种衍生产品,包括与荧光染料偶联的抗体。除了可靠的上样控制和标签抗体外,我们的目录还包括1000多种识别具有磷酸化,乙酰化或甲基化修饰的蛋白质的特异性抗体。我们公司承诺以强大,优质的科学支持快速交货。Bioss Inc位于马萨诸塞州的大波士顿地区,该地区是世界上最大,发展最快的生物技术社区的中心。


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biossusa的ACE2(血管紧张素I转换酶2)是一种蛋白质编码基因。与ACE2相关的疾病包括严重急性呼吸系统综合症和神经性高血压。该基因编码的蛋白属于二肽基羧二肽酶的血管紧张素转化酶家族,与人类血管紧张素1转化酶具有相当的同源性。这种分泌的蛋白质催化血管紧张素I裂解为血管紧张素1-9,而血管紧张素II裂解为血管扩张剂血管紧张素1-7。

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