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biossusa/FOXO1 Polyclonal Antibody, HRP Conjugated/100ul/bs-2537R-HRP

biossusa/FOXO1 Polyclonal Antibody, HRP Conjugated/100ul/bs-2537R-HRP
  • biossusa/FOXO1 Polyclonal Antibody, HRP Conjugated/100ul/bs-2537R-HRP
商品介绍
Overview
Catalog #bs-2537R-HRP
Product NameFOXO1 Polyclonal Antibody, HRP Conjugated
ApplicationsWB, ELISA, IHC-P, IHC-F
ReactivityHuman, Mouse, Rat
Predicted ReactivityDog, Cow, Pig
Specifications
ConjugationHRP
HostRabbit
SourceKLH conjugated synthetic peptide derived from human FOXO1
Immunogen Range201-300/655
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID2308
Swiss ProtQ12778
Subcellular locationCytoplasm, Nucleus
SynonymsFKH1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1
BackgroundTranscription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5"-TT[G/A]TTTTG-3" and the related Daf-16 family binding element (DBE) with consensus sequence 5"-TT[G/A]TTTAC-3". Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
Application Dilution
WB1:300-1000
ELISA1:500-1000
IHC-P1:200-400
IHC-F1:100-500
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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