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biossusa/TGF Beta R1 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/100ul/bs-0638R-A680

biossusa/TGF Beta R1 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/100ul/bs-0638R-A680
  • biossusa/TGF Beta R1 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated/100ul/bs-0638R-A680
商品介绍
Overview
Catalog #bs-0638R-A680
Product NameTGF Beta R1 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated
ApplicationsIF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman, Mouse, Rat
Predicted ReactivityCow
Specifications
ConjugationALEXA FLUOR® 680
HostRabbit
SourceKLH conjugated synthetic peptide derived from human TGF-beta R1
Immunogen Range301-400/501
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID7046
Swiss ProtP36897
Subcellular locationCell membrane
SynonymsAAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; TGF-beta receptor type-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; Serine/threonine-protein kinase receptor R4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I; TGFBR1
BackgroundTransmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
Application Dilution
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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