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biossusa/GPR30 Polyclonal Antibody, Cy5 Conjugated/100ul/bs-1380R-Cy5

  • 产品编号: bs-1380R-Cy5
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌: biossusa
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类: 抗体类>二抗>抗小鼠>
  • 公司分类:
biossusa/GPR30 Polyclonal Antibody, Cy5 Conjugated/100ul/bs-1380R-Cy5
  • biossusa/GPR30 Polyclonal Antibody, Cy5 Conjugated/100ul/bs-1380R-Cy5
商品介绍
Overview
Catalog #bs-1380R-Cy5
Product NameGPR30 Polyclonal Antibody, Cy5 Conjugated
ApplicationsFCM, IF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman, Mouse, Rat
Predicted ReactivityCow, Horse, Chicken, Rabbit
Specifications
ConjugationCy5
HostRabbit
SourceKLH conjugated synthetic peptide derived from human GPR30
Immunogen Range251-375/375
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID2852
Swiss ProtQ99527
Subcellular locationCytoplasm, Nucleus, Cell membrane, Extracellular matrix
SynonymsmER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br; G-protein coupled estrogen receptor 1; Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor; Membrane estrogen receptor; GPER1
BackgroundG-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.
Application Dilution
FCM1:20-100
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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