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biossusa/TIE2/CD202b Polyclonal Antibody, FITC Conjugated/100ul/bs-1300R-FITC

  • 产品编号: bs-1300R-FITC
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类:
  • 公司分类: Primary Antibodies
biossusa/TIE2/CD202b Polyclonal Antibody, FITC Conjugated/100ul/bs-1300R-FITC
  • biossusa/TIE2/CD202b Polyclonal Antibody, FITC Conjugated/100ul/bs-1300R-FITC
商品介绍
Overview
Catalog #bs-1300R-FITC
Product NameTIE2/CD202b Polyclonal Antibody, FITC Conjugated
ApplicationsFCM, IF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman, Rat
Predicted ReactivityMouse, Cow, Pig, Horse
Specifications
ConjugationFITC
HostRabbit
SourceKLH conjugated synthetic peptide derived from human Tie2
Immunogen Range401-550/1120
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID7010
Swiss ProtQ02763
Subcellular locationCytoplasm, Secreted, Cell membrane
SynonymsTIE2; VMCM; TIE-2; VMCM1; CD22B; Angiopoietin-1 receptor; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p14 TEK; TEK
BackgroundTyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1.
Application Dilution
FCM1:20-100
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

Bioss Inc是领先的抗体开发人员和制造商,拥有最先进的技术。我们已经开发了11,000多种一抗和130,000多种衍生产品,包括与荧光染料偶联的抗体。除了可靠的上样控制和标签抗体外,我们的目录还包括1000多种识别具有磷酸化,乙酰化或甲基化修饰的蛋白质的特异性抗体。我们公司承诺以强大,优质的科学支持快速交货。Bioss Inc位于马萨诸塞州的大波士顿地区,该地区是世界上最大,发展最快的生物技术社区的中心。


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