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biossusa/NFKB p65 Polyclonal Antibody, FITC Conjugated/100ul/bs-0465R-FITC

  • 产品编号: bs-0465R-FITC
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌: biossusa
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类: 抗体类>二抗>抗猫>
  • 公司分类:
biossusa/NFKB p65 Polyclonal Antibody, FITC Conjugated/100ul/bs-0465R-FITC
  • biossusa/NFKB p65 Polyclonal Antibody, FITC Conjugated/100ul/bs-0465R-FITC
商品介绍
Overview
Catalog #bs-0465R-FITC
Product NameNFKB p65 Polyclonal Antibody, FITC Conjugated
ApplicationsFCM, IF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman, Mouse, Rat, Zebrafish
Predicted ReactivityDog, Cow, Pig, Horse, Chicken, Rabbit
Specifications
ConjugationFITC
HostRabbit
SourceKLH conjugated synthetic peptide derived from human NFKBp65
Immunogen Range51-100/551
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID5970
Swiss ProtQ04206
Subcellular locationCytoplasm, Nucleus
Synonymsp65; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; RELA
BackgroundNF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p15, NFKB1/p5, REL and NFKB2/p52 and the heterodimeric p65-p5 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p5 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
Application Dilution
FCM1:20-100
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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