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biossusa/IKBKE Polyclonal Antibody, Cy5 Conjugated/100ul/bs-4114R-Cy5

  • 产品编号: bs-4114R-Cy5
  • 美  元  价: $402.00
  • 市  场  价: ¥8040.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: biossusa
  • 产品分类:
  • 公司分类: Primary Antibodies
biossusa/IKBKE Polyclonal Antibody, Cy5 Conjugated/100ul/bs-4114R-Cy5
  • biossusa/IKBKE Polyclonal Antibody, Cy5 Conjugated/100ul/bs-4114R-Cy5
商品介绍
Overview
Catalog #bs-4114R-Cy5
Product NameIKBKE Polyclonal Antibody, Cy5 Conjugated
ApplicationsIF(IHC-P), IF(IHC-F), IF(ICC)
ReactivityHuman
Predicted ReactivityMouse, Rat, Cow
Specifications
ConjugationCy5
HostRabbit
SourceKLH conjugated synthetic peptide derived from human IKBKE
Immunogen Range501-600/716
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at 4°C for 12 months.
Target
Gene ID9641
Swiss ProtQ14164
Subcellular locationCytoplasm, Nucleus
SynonymsIKKE; IKKI; IKK-E; IKK-i; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; KIAA0151
BackgroundSerine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at "Ser-708". Phosphorylation of STAT1 at "Ser-708" seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
Application Dilution
IF(IHC-P)1:50-200
IF(IHC-F)1:50-200
IF(ICC)1:50-200
品牌介绍

Bioss Inc是领先的抗体开发人员和制造商,拥有最先进的技术。我们已经开发了11,000多种一抗和130,000多种衍生产品,包括与荧光染料偶联的抗体。除了可靠的上样控制和标签抗体外,我们的目录还包括1000多种识别具有磷酸化,乙酰化或甲基化修饰的蛋白质的特异性抗体。我们公司承诺以强大,优质的科学支持快速交货。Bioss Inc位于马萨诸塞州的大波士顿地区,该地区是世界上最大,发展最快的生物技术社区的中心。


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