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biossusa/RAB7 Polyclonal Antibody, Biotin Conjugated/100ul/bs-6703R-Biotin

biossusa/RAB7 Polyclonal Antibody, Biotin Conjugated/100ul/bs-6703R-Biotin
  • biossusa/RAB7 Polyclonal Antibody, Biotin Conjugated/100ul/bs-6703R-Biotin
商品介绍
Overview
Catalog #bs-6703R-Biotin
Product NameRAB7 Polyclonal Antibody, Biotin Conjugated
ApplicationsWB, ELISA, IHC-P, IHC-F
ReactivityHuman, Mouse
Predicted ReactivityRat, Dog, Cow, Sheep, Pig, Horse, Rabbit
Specifications
ConjugationBiotin
HostRabbit
SourceKLH conjugated synthetic peptide derived from human RAB7
Immunogen Range101-207/207
ClonalityPolyclonal
IsotypeIgG
Concentration1ug/ul
PurificationPurified by Protein A.
Storage BufferAqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage ConditionStore at -20°C for 12 months.
Target
Gene ID7879
Swiss ProtP51149
Subcellular locationCytoplasm
SynonymsRAB7; PRO276; Ras-related protein Rab-7a; RAB7A
BackgroundKey regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.
Application Dilution
WB1:300-1000
ELISA1:500-1000
IHC-P1:200-400
IHC-F1:100-500
品牌介绍

biossusa的最终目标是改善人类和动物的健康和生活质量。为了对抗COVID-19,Bioss开发了抗体,蛋白质和ELISA试剂盒来支持新型冠状病毒的研究。 

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